Part 2: Health apps, wearables, and sensors: The advancing frontier of digital health

The Dutch case involved sophisticated financial professionals, people accustomed to analyzing financial and economic trends. Yet, they too focused on their personal experience.
根据花旗居屋(Citi Habitats)提供的数据,在布鲁克林拟于明年投放市场的6527套新出租屋中,有1442套分布在贝德福德-斯图文森(Bedford-Stuyvesant)、布什维克(Bushwick)和克林顿山(Clinton Hill)。就在不久前,这些社区都还被视为不热门的地区。
卡尔说:“如果要打赌的话,我赌今年比去年更热。”
Some hits have gone so far over the top they should be winded, yet instead keep on puffing gusts of hot air, including “Downton Abbey,” “Scandal” and “Revenge.” A new addition on ABC, “How to Get Away With Murder” was a fun substitute, a lurid nighttime soap opera about lawbreaking defense lawyers — “Law & Disorder.”
巴里摩尔的病情基于米歇尔·菲利普斯的真实生活,她的头部在在两次机动车事故中受伤,记忆只能维持24小时。桑德勒用录像带,菲利普斯则是用便利贴和手机(对她而言还真时髦)撑了23年。
9、《神奇动物在哪里》
银行根本无力赶上这样的薪酬水平。例如,受交易结构性变化和旨在约束冒险行为的新规打击,自2009年以来高盛(Goldman Sachs)的净收入减少了约三分之一。该行试图让薪酬比保持稳定,这意味着发放给典型员工的总薪酬减少。
格陵兰鲨活得很久
《在生前留下的物品中回忆世界上最长寿的人》(Remembering the World’s Oldest Person, in the Objects She Left Behind)
你花在上网上的时间多于你工作的时间
"这是自然保护的一次伟大创举。"
So here are the main items to take into consideration if you’re trying to develop a business platform. These elements constitute will support a smart strategy for any new enterprise:
谎言2:好的,我会尽快开工的!说谎原因:如果我告诉你在做你要求的这件事之前,我还有10件事要做的话,你肯定会抓狂的。
中国台湾台东——这座连接了无人小岛三仙岛和台东县的人行桥非常有名,因为它由8座拱桥相连而成。在《孤独星球》2016年“亚洲最佳景点”中,这座沿海小县城也名列其中。
9. Am I spending too much? Overspending can lead to stress, clutter, and financial complications. It can also turn into a nasty habit over time. Saving money is an excellent practice and you will more than likely be glad you did in case of an emergency.
11月,财新-Markit制造业采购经理人指数(PMI)从10月的51%降至50.8%,接近区分扩张和收缩的50%大关。此前,路透社(Reuters)对经济学家进行调查得出的预测中值曾预计,制造业PMI将降至50.9%。
去年,伊斯兰国激进分子在土耳其驻摩苏尔领事馆扣押了49名土耳其人质,三个多月后才释放他们。人质中包括外交官、军人和儿童。
1. What big brother is eating isn’t noodles, but loneliness.
但是,欧洲央行宣布决定后市场暴跌。投资者抱怨称,这家央行此前在其准备注入多少额外刺激以支撑复苏的问题上误导了市场。
《纸牌屋》(House of Cards),Netflix,2月27日播出。Netflix的政治大戏,第三季有13集。除凯文·斯派西(Kevin Spacey)与罗宾·怀特(Robin Wright)外,曾出演《忧愁河上桥》(Treme)的基姆·迪金斯(Kim Dickens)亦加盟该剧,“Pussy Riot”的两位成员亦有客座出演。
The government's next snapshot of the job market, due Friday, will be distorted by Sandy, which devastated the Northeast in late October, leaving many jobless. Economists say Sandy could temporarily knock anywhere from 100,000 to 150,000 off of the government's jobs tally for November, resulting in job growth of under 100,000 or even much less.[qh]
Ronaldo and Messi are the only football players in the top 20, which also features no women.
Battle of the box office 电影贺岁档引发票房PK
The World Health Organization this year declared H1N1 a global epidemic. Fortunately, it is much less threatening than people previously believed, and newly introduced vaccines seem to have quelled lingering fears.
In the meantime, here’s a fun song that’s been written by one of my readers, Libby Russell that all football widows will identify with. Enjoy! Thank you for sharing, Libby. It’s brilliant!


n. 路线,(固定)线路,途径
但是,小牛队的确应该摆烂。同样的还有国王队,还有热火队,还有魔术队。这些都是中游的球队,即使在最乐观的预测中都没有很高的排名。
周一晚间,安卡拉方面证实,不欢迎荷兰驻土耳其大使返回土耳其。


With the increasing proliferation and sophistication of mobile phones, wearable devices such as smart watches, and sensors that can measure and gather a variety of data, public interest is growing in using consumer electronics to take ownership of personal health and wellness. A 2015 survey found that 66% of Americans age 66 and older want to use mobile technologies to improve their health by receiving medication reminders and tracking diet and nutrition, physical activity, and symptoms.[1

展示自己,每时每刻
“This is our make or break moment for the tenant movement,” said Ilana Maier, the program director for the Metropolitan Council on Housing. “If we aren’t able to drastically strengthen the rules now, none of this will matter in 10 years.”
MasterCard says its index reflects the interconnectedness of major global cities and tracks the ways in which business and leisure jet-setters spend their money.
Agents and investment institutions are now flooding the sector, causing additional changes to content and platforms in the world's second-largest economy, the report said. A number of Internet gurus, including Lei Jun, investor and founder of tech firm Xiaomi, Zhou Hongyi, CEO of Qihoo 360 Technology, and China's richest man Wang Jianlin have all directly supported live video-streaming websites, a strong indication of the growing interest from capital investment.

Health apps and wearables
Health apps and wearables can unobtrusively gauge physiological and emotional states and collect, quantify, and monitor data regarding a user’s day-to-day behaviors. This “quantified self” can increase users’ self-awareness regarding their behavior and encourage positive changes to their overall health and well-being.[2] These commercially available devices also integrate an array of features to provide motivation through reward systems, opportunities for social in-teraction, tools for self-improvement, and prompts. The novelty, affordability, practicality, and ease of use have resulted in increased consumer enthusiasm and the pervasiveness of these devices.[3,4] With this growing interest in personal health, members of the general public are becoming more involved in monitoring and improving their own health habits.[5-10

Undoubtedly, merely tracking data through a device is not enough to maintain good health-related behaviors long-term, and the software must also incorporate motivational constructs important for the adoption and habituation of behaviors. For instance, a systematic review of studies that considered the use of electronic activity monitor systems found short-term changes in physical activity with self-monitoring, but no demonstration of superiority when the systems were compared with other interventions.[11] Another review of studies on the viability of using mobile technology for measuring and influencing physical activity found that most apps allow users to document their activity, set goals, review real-time feedback, connect to a social support network, and access online expertise.[12] However, less common among these apps were prompts to act and opportunities for problem solving and action planning, which are crucial constructs that translate intention into long-term behavior change.[13]

Sensor technologies
Sensor technologies have begun to enter the telehealth landscape and are primarily focused on continuous monitoring and precise diagnostics to inform management of various health conditions and diseases.[14-17] Sensors can be integrated into a watch or arm band or adhesive bandages and clothing, and then programmed to collect data on cardiac rhythm, heart rate, blood pressure, respiration, oxygen saturation, galvanic skin response, glucose levels, body temperature, body motions, ambient temperature, and global positioning. For health care providers, sensor inputs can permit remote monitoring, real-time teleconferencing, and timely care for patients with chronic diseases. For both patients and clinicians, telehealth supported by sensors can have profound implications. Clinicians can provide timely and patient-centred care to those living at a distance with chronic disease and can coordinate care when multiple providers are involved, reducing costs to the health care system.

A current clinical example is the management of paroxysmal atrial fibrillation with a mobile ECG and app that monitors the patient’s electrical rhythm to detect frequency and patterns of arrhythmias, and may even allow patients to share ultrasound and electrocardiogram data with their health care provider.[18-20] Telemonitoring with sensors can also support self-management of chronic diseases and detect early signs of deterioration in health requiring immediate treatment and advice.[21] Studies to date have demonstrated some clinical promise for the use of home telemonitoring in the context of heart failure and diabetes. A recent Cochrane review found that telemonitoring was an effective way to lower levels of glycated hemoglobin and low-density lipoprotein.[22] Although several studies on heart failure have produced conflicting results regarding the overall benefits of home monitoring,[23-26] systematic reviews have suggested that home telemonitoring reduces all-cause mortality and hospitalizations, and improves quality of life compared with usual care.[22,27] In addition, features such as automated and mobile telemonitoring appear to be more effective compared with other forms of home telemonitoring.[27]

Further studies are needed to determine how home health monitoring can improve patient safety during the transition from acute care to community care, and to examine the impact of home monitoring on health care costs. TEC4Home (Telehealth for Emergency-Community Continuity of Care Connectivity via Home Tele-monitoring), an initiative of the University of British Columbia and Vancouver Coastal Health, is seeking to do this with prospective trials designed to uncover how telemonitoring can support the safety of heart failure patients discharged from hospital to home.[28]

Mobile apps, wearables, and sensors in the clinical setting
Even though mobile apps, wearables, and sensor technologies are promising, further research is needed to validate their use and long-term impact.[29] This research will require the collaboration of clinicians, health researchers, engineers, and computer scientists.[30] Understanding the possible risks of using these technologies, from physiological harm to breaching of privacy and confidentiality with insecure devices, and how to mitigate any risks is also important. Other important issues to consider include patient anxiety with overuse of technologies, health data piracy, self-diagnosis resulting from overreliance on self-monitoring, and patients not seeking help appropriately. These technologies should be used only as complementary tools in the treatment and prevention of health conditions and disease and should not be used in isolation by patients who self-diagnose and self-manage without consulting a health professional. 

Though many people associate Porsche with pure performance cars, in recent years the brand has expanded their lineup to include the Panamera, a luxury large car shown here, as well as the Cayenne and Macan SUVs. According to most reviewers, the Panamera not only lives up to the performance heritage of the Porsche’s brand, but also coddles occupants with an opulent interior and the connectivity features today’s luxury buyer demands.

Instant Heart Rate by Azumio.[31] A free app downloadable to both Apple and Android operating systems that measures heart rate and displays a monitoring strip. As well as helping users accurately track their heart rates, the app is capable of detecting irregular rhythms when palpitations occur. 

Sleep Time by Azumio.[32] A free app that monitors sleep patterns, sleep efficiency, and also acts as an alarm clock. Users can know how often they go into light and deep sleep, and recognize how much of these types of sleep will be necessary for them to feel rested, thereby quantifying the amount of true sleep they need and not just how long they should stay in bed. 

Bellybio Interactive Breating by RelaxLine.[33] A free app that helps users pace their breathing to achieve calmness. Placing the mobile phone against the abdomen, users can follow the sounds emitted to practise deep, abdominal breathing using this simple yet surprisingly effective tool. 

Two Chinese universities, University of Hong Kong and University of Macao, squeezed into the top 10 of the world's most international universities in 2016, according to a new list published by Times Higher Education on Thursday.
对投资者而言,今年对行业的准确判断还只是个小问题,因为除了美股,今年全球的投资好选择不多。

《请以你的名字呼唤我 》
4. Slacking at school
这些利好消息为特斯拉带来了极为惊人的估值。一位名叫佐尔坦o班的特斯拉观察人士在金融网站“寻找阿尔法“(Seeking Alpha)上指出,特斯拉现在的估值,相当于它每年已经能够卖出几十万辆汽车,但实际上今年它只能卖出35,000多辆车。从另一个角度来说,特斯拉公司今年卖出的每一台车,估值相当于高达100万美元。
卓越雇主排名:12
据Birinyi收集的数据,下面是今年迄今已经获得授权的5大回购。
Part of the appeal of online programmes lies in their flexibility, reach and slower pace of delivery than cam-pus-based MBAs. Apart from IE, which imposes an 18-month time limit, participants have on average about five years to complete their degrees.

Discernment to determine whether a particular app, wearable, or sensor can be effective.
Expertise and experience to guide patients on the use of technology.
Partnership with patients in pursuit of optimal health through technology use.
Trials to closely monitor benefits and drawbacks.
Humility to recognize that patients may know and invest much more time than physicians in looking for these tools.34

Conclusions
Based on today’s rapid pace of development and public enthusiasm for the technology marketplace, health apps, wearables, and sensors will soon become integral to our patients’ pursuits of good health and will need to be integrated in clinical practice. Physicians must be active agents in these evolutionary times, guiding patients, advocating for evidence to support the use of technologies, and participating in the development and incorporation of technology in patient wellness journeys. Through clinical stewardship and partnership with patients, physicians can use their expertise and experience to guide the growth of innovations into mainstream health care.

Competing interests
Dr Ho receives no personal financial compensation as the principal investigator of TEC4Home (Telehealth for Emergency-Community Continuity of Care Connectivity via Home Tele-monitoring), a project funded by a Canadian Institutes of Health Research grant. This grant is matched by the Michael Smith Foundation for Health Research and the BC Ministry of Health, with additional support provided by TELUS Health and Sentrian. TELUS Health, Cisco, and Avizia have also provided equipment for display in Dr Ho’s Demonstration and Simulation Studio for Health (DaSSH) at UBC. Mr Yao and Dr Lauscher have no competing interests to declare.


物流地产受追捧


References

1. Cision PR Newswire. Fifth annual Pulse of Online Health survey finds 66% of Americans eager to leverage digital tools to manage personal health. Posted 24 February 2015. Accessed 28 August 2017. www.prnewswire.com/news-releases/fifth-annual-pulse-of-online-health-survey-finds-66-of-americans-eager-to-leverage-digital-tools-to-manage-personal-health-300039986.html.

2. Swan M. Emerging patient-driven health care models: An examination of health social networks, consumer personalized medicine and quantified self-tracking. Int J Environ Res Public Health 2009;6:492-525.

3. Gao Y, Li H, Luo Y. An empirical study of wearable technology acceptance in healthcare. Ind Manag Data Syst 2010;115:1704-1723.

4. Kim KJ, Shin DH. An acceptance model for smart watches: Implications for the adoption of future wearable technology. Internet Res 2015;25:527-541.

5. West JH, Hall PC, Hanson CL, et al. There’s an app for that: Content analysis of paid health and fitness apps. J Med Internet Res 2012;14:e72.

6. Abroms LC, Padmanabhan N, Thaweethai L, Phillips T. iPhone apps for smoking cessation: A content analysis. Am J Prev Med 2011;40:279-285.

7. Cowan LT, Van Wagenen SA, Brown BA, et al. Apps of steel: Are exercise apps providing consumers with realistic expectations? A content analysis of exercise apps for presence of behavior change theory. Health Educ Behav 2013;40:133-139.

8. Azar KM, Lesser LI, Laing BY, et al. Mobile applications for weight management. Am J Prev Med 2013;45:583-589.

9. Breland JY, Yeh VM, Yu J. Adherence to evidence-based guidelines among diabetes self-management apps. Transl Behav Med 2013;3:277-286.

10. Lyons EJ, Lewis ZH, Mayrsohn BG, Rowland JL. Behavior change techniques implemented in electronic lifestyle activity monitors: A systematic content analysis. J Med Internet Res 2014;16:e192.

11. Lewis ZH, Lyons EJ, Jarvis JM, Baillargeon J. Using an electronic activity monitor system as an intervention modality: A systematic review. BMC Public Health 2015;15:585.

12. Bort-Roig J, Gilson ND, Puig-Ribera A, et al. Measuring and influencing physical activity with smartphone technology: A systematic review. Sports Med 2014;44:671-686.

13. Rhodes RE, Yao CA. Models accounting for intention-behavior discordance in the physical activity domain: A user’s guide, content overview, and review of current evidence. Int J Behav Nutr Phys Act 2015;12:1-14.

14. Chen M, Gonzalez S, Vasilakos A, et al. Body area networks: A survey. Mob Networks Appl 2011;16:171-193.

15. Appelboom G, Camacho E, Abraham ME, et al. Smart wearable body sensors for patient self-assessment and monitoring. Arch Public Health 2014;72:28.

16. Chan M, Estève D, Fourniols JY, et al. Smart wearable systems: Current status and future challenges. Artif Intell Med 2012;56:137-156.

17. Alemdar H, Ersoy C. Wireless sensor networks for healthcare: A survey. Comput Networks 2010;54:2688-2710.

18. Haberman ZC, Jahn RT, Bose R, et al. Wireless smartphone ECG enables large-scale screening in diverse populations. J Cardiovasc Electrophysiol 2015;26:520-526.

19. Ferdman DJ, Liberman L, Silver ES. A smartphone application to diagnose the mechanism of pediatric supraventricular tachycardia. Pediatr Cardiol 2015;36:1452-1457.

20. Baquero GA, Banchs JE, Ahmed S, et al. Surface 12 lead electrocardiogram recordings using smart phone technology. J Electrocardiol 2015;48:1-7.

21. Wootton R. Twenty years of telemedicine in chronic disease management—An evidence synthesis. J Telemed Telecare 2012;18:211-220.

22. Flodgren G, Rachas A, Farmer A, et al. Interactive telemedicine: Effects on professional practice and health care outcomes. Cochrane Database System Rev 2015;(9):CD002098.

23. Mortara A, Pinna GD, Johnson P, et al. Home telemonitoring in heart failure patients: The HHH study (Home or Hospital in Heart Failure). Eur J Heart Fail 2009;11:312-318.

24. Dar O, Riley J, Chapman C, et al. A randomized trial of home telemonitoring in a typical elderly heart failure population in North West London: Results of the Home-HF study. Eur J Heart Fail 2009;11:319-325.

25. Chaudhry SI, Mattera JA, Curtis JP, et al. Telemonitoring in patients with heart failure. N Engl J Med 2010;363:2301-2309.

26. Koehler F, Winkler S, Schieber M, et al. Impact of remote telemedical management on mortality and hospitalizations in ambulatory patients with chronic heart failure: The Telemedical Interventional Monitoring in Heart Failure study. Circulation 2011;123:1873-1880.

27. Kitsiou S, Pare G, Jaana M. Effects of home telemonitoring interventions on patients with chronic heart failure: An overview of systematic reviews. J Med Internet Res 2015;17:e63.

28. TEC4Home Healthcare Innovation Community. Supporting heart failure patient transitions from acute to community care with home telemonitoring technology: A protocol for a provincial randomized controlled trial (TEC4Home). JMIR Res Protoc 2016;5:e198. 

29. Yao C, Ho K. Mobile sensors and wearable technologies. In: Amelung VE, Stein V, Goodwin N, et al., editors. Handbook integrated care. Cham, Switzerland: Springer; 2017.

30. Ho K, Borycki E, Kushniruk A, et al. The health perspective in using digital media for health and wellness. Presented at the IEEE International Digital Media Industry Forum, Boston, MA, 4-6 July 2016.

31. Azumio Inc. Instant heart rate. Accessed 28 August 2017. www.azumio.com/s/instantheartrate/index.html. 

32. Azumio Inc. Sleep time. Accessed 28 August 2017. www.azumio.com/s/sleeptime/index.html. 

33. RelaxLine. BellyBio. Accessed 28 August 2017. https://itunes.apple.com/ca/app/bellybio-interactive-breathing/id353763955?mt=8.

34. Ho K. How health information technologies are enhancing health of patients and their doctors. Presentation at the Alberta Medical Association 2015 Spring Representatives Forum, Edmonton, AB, 13 March 2015.


美国谷歌搜索2017排名前十
匹兹堡大学的研究小组从来自皮肤的干细胞培养出MCPs,一种可以作为心血管组织驱动器的特殊细胞。他们把这些细胞放在一种可以维持老鼠心脏的3-D支架上。在20天内,新的心脏开始以每分钟40~50次的速率搏动。
SETTING: This house is in Kenwood, a neighborhood of 19th- and 20th-century Tudors, Mediterraneans, Victorians and colonial-style houses between Cedar Lake and Lake of the Isles, in the city’s Chain of Lakes. Roads are curving; sidewalks are lined with maple and ash trees. According to the listing agent, many of the neighborhood’s older houses have been restored, while houses built within the last 30 years have been torn down and replaced.
《财富》美国500强公司美国电话电报公司(AT&T))也于3月份批准了回购至多3亿股股票的计划,价值约105亿美元。这项回购计划是它过去三年中宣布的第四项回购计划。这家公司自从2012年开始股票回购至今,总计已经回购了7.75亿股的股票。
观看《皮囊之下》再次让我想起另外一个比较:奥逊·威尔斯,成功的用收音机创造了火星入侵的骗局;还有《赝品》(1975)中,那个让他的伙伴奥佳·柯达穿着迷你短裙走在街上,然后偷偷拍摄那些男人们看她的淫荡表情。
Justin Bieb er just made tens of thousands of more dollars -- from his hair. The 'Baby' singer's locks sold on eBay yesterday with a final bid of $40,688.
声明中说:“我们真诚地向《月光男孩》剧组、《爱乐之城》剧组、沃伦?比蒂、费?唐纳薇和奥斯卡颁奖礼观众致歉,因为在宣布最佳影片环节中我们出了纰漏。”
这确实是的。不过费城队近年来如此努力地垫底的一个被忽略的好处是:他们是如此地烂,以至于这会让其他竞相垫底的球队产生挫败感,因为他们很难做到和76人一样烂。在76人面前,小牛队至少只能算是中等水平的烂。
根据独立健康慈善金基金的分析,到2021年,医疗预算将持续缩减大概8亿欧元(超过10亿美金),尤其是在性健康和性传染病方面的缩减。
持有40亿美元亚洲相关资产的美国投资机构Cohen & Steers的基金经理梁纬濂(William Leung)认同这一点。他主张,随着价格下跌,投机性投资将被驱逐出市场。他补充称,行业中另类投资热度上升的趋势应当意味着,即便基础资产的价值上涨得更慢,房地产投资信托的价格也会上升。“我们认为,这次调整的幅度将不会太大,”他说。

Kendall Ho, MD, FRCPC, Christopher Yao, MSc, Helen Novak Lauscher, PhD. Part 2: Health apps, wearables, and sensors: The advancing frontier of digital health. BCMJ, Vol. 59, No. 10, December, 2017, Page(s) 503-506 - Clinical Articles.



Above is the information needed to cite this article in your paper or presentation. The International Committee of Medical Journal Editors (ICMJE) recommends the following citation style, which is the now nearly universally accepted citation style for scientific papers:
Halpern SD, Ubel PA, Caplan AL, Marion DW, Palmer AM, Schiding JK, et al. Solid-organ transplantation in HIV-infected patients. N Engl J Med. 2002;347:284-7.

About the ICMJE and citation styles

The ICMJE is small group of editors of general medical journals who first met informally in Vancouver, British Columbia, in 1978 to establish guidelines for the format of manuscripts submitted to their journals. The group became known as the Vancouver Group. Its requirements for manuscripts, including formats for bibliographic references developed by the U.S. National Library of Medicine (NLM), were first published in 1979. The Vancouver Group expanded and evolved into the International Committee of Medical Journal Editors (ICMJE), which meets annually. The ICMJE created the 《边桥谜案》(The Bridge),Hulu,周五播出。这部丹麦、瑞典合拍的犯罪剧即将迎来第二季(FX的同名剧集就是根据它改编的,最近刚刚被砍掉),新的一季仍与连接两个乡村的奥莱桑德桥有关。 to help authors and editors create and distribute accurate, clear, easily accessible reports of biomedical studies.

Arlie Russell Hochschild, the author of “Strangers in Their Own Land: Anger and Mourning on the American Right,” describes a feeling of lost opportunity as the “deep story” of the rural Louisiana communities she spent four years studying.
McCarthy took home $33 million in earnings, up $10 million from 2015.
Earlier on Tuesday Mr Rutte had issued a call for calm in the dispute with Turkey.
"绝望主妇"伊娃与老公的性感广告宣传照

Effective bosses and managers tend to:

  • Only the first three authors are listed, followed by "et al."
  • 中央深改委:赋予雄安新区更大改革自主权
  • 揭秘水泥粗钢产量背离:建材“扛把子”品种走岔了


Screengrab taken on January 11, 2015 from a video released on Islamist social networks shows a man claiming to be Amedy Coulibaly, who killed four hostages after seizing a Kosher supermarket in Parison January 9, 2015 (AFP Photo/)
在接下来的几个月里,金州勇士就恢复正常了。因为凯文·杜兰特受伤,让斯蒂芬·库里重新成为那个无所不能的斯蒂芬·库里,当凯文·杜兰特重返球队的时候,球队也在他们这两个MVP之间找到了平衡。于是季后赛横扫西部的可怕爆发显然可以预料得到。开拓者被打的毫无还手之力,爵士拼尽全力但仍无法获得一场比赛。本来马刺很有可能拿下一场比赛,在那场比赛中他们一度领先20分,然后,当扎扎帕楚里亚垫了一只脚之后,科怀·伦纳德便受伤了,结果就是这样。

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